mB12

The methylation cycle runs on two reactions: methionine synthase (which requires methylcobalamin as a cofactor) and the folate cycle (which requires 5-MTHF to regenerate methionine from homocysteine). An estimated 30 to 40% of the population carries MTHFR variants (C677T or A1298C) that reduce the body's ability to activate folic acid. MB12 bypasses those bottlenecks entirely.

Individuals with known MTHFR polymorphisms, elevated homocysteine, or provider-directed high-dose methylation support. Also appropriate for anyone with confirmed B12 deficiency or methylation-related concerns that require more than maintenance-level supplementation.

Take with a meal, preferably in the morning. Methylated B vitamins can be energizing and may interfere with sleep if taken late in the day.

High-dose methylfolate can cause irritability, anxiety, or insomnia in some individuals, particularly those who are overmethylators or have COMT polymorphisms. If you experience agitation or sleep disruption, reduce the dose or take in the morning only.

SAMe
MB12 supports the methylation cycle that regenerates SAMe, making them a natural pairing for comprehensive methylation support.

Super B Complex
A full B complex provides the additional B vitamins (B2, B6) needed as cofactors elsewhere in the methylation and transsulfuration pathways.

Mag Threonate
Magnesium is a cofactor in numerous methylation-dependent reactions, and the threonate form supports the neurological benefits of healthy methylation.

🎁 Part of The MTHFR Stack. Methylcobalamin + methylfolate in their final bioactive forms, completely bypassing MTHFR. Paired with SAMe and a methylated multi.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Talk with your healthcare provider before starting any new supplement routine.