SAMe

✓SAMe is a methyl donor critical to the synthesis of serotonin, dopamine, and norepinephrine, supporting healthy mood and emotional balance.

✓Supports proteoglycan synthesis in cartilage, contributing to joint cushioning and flexibility over time.

✓Essential for glutathione production and phase II methylation conjugation in the liver, supporting healthy detoxification.

✓Quatrefolic methylfolate ensures SAMe is efficiently recycled through the methionine cycle, even in individuals with MTHFR variants that limit folate activation.

SAMe works through a cycle: it donates a methyl group, becomes homocysteine, and then must be recycled back to methionine (and eventually SAMe again) via the folate-dependent remethylation pathway. Without adequate active folate, this cycle stalls and homocysteine accumulates. Quatrefolic, the glucosamine salt of 5-MTHF, bypasses MTHFR polymorphisms that can limit folate activation, keeping the methylation cycle running efficiently.

People seeking support for mood balance, joint comfort, or liver health, particularly those with known methylation challenges, MTHFR polymorphisms, or elevated homocysteine levels that suggest the methylation cycle could use upstream support.

Take on an empty stomach, 30 to 60 minutes before a meal. SAMe absorbs best without food and is most effective when taken in the morning.

SAMe may interact with serotonergic medications (SSRIs, SNRIs, MAOIs, tricyclics, triptans). If you take any psychiatric medication, consult your prescriber before use.

Super B Complex
B vitamins (especially B6, B12, and folate) are essential cofactors in the methylation cycle that recycles SAMe.

MB12
High-dose methylcobalamin further supports the methionine synthase reaction that regenerates SAMe.

Turmeric
Curcumin complements SAMe's joint support through a different mechanism, addressing inflammatory signaling in joint tissue.

🎁 Part of the Mood Lift bundle. SAMe is the universal methyl donor supporting neurotransmitter synthesis, paired with precursors, omega-3, and methylated B vitamins.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Talk with your healthcare provider before starting any new supplement routine.