The Perimenopause Protocol

Estro-Fem
ERr 731 rhapontic rhubarb extract at the dose used in the Heger et al.

DIM-CDG
DIM (diindolylmethane) supports healthy estrogen metabolism, critical as estrogen levels fluctuate during perimenopause.

Magnesium
Triple-form chelated magnesium for sleep quality and mood stability.

Calm
GABA + Suntheanine L-Theanine for nervous system calming.

Pregnenolone
Upstream precursor to all steroid hormones.

✓ Who this is for

Women navigating perimenopause who are experiencing hot flashes, night sweats, sleep disruption, mood shifts, anxiety, or brain fog. Women who have felt dismissed by conventional medicine and want a functional approach to the menopausal transition.

✗ Who this is not for

Women with ER-positive breast cancer history (ERr 731 and DIM both modulate estrogen pathways; consult your oncologist). Women on hormone replacement therapy without practitioner coordination.

Morning with breakfast: Estro-Fem ERr 731 (1 capsule) and DIM-CDG (2 capsules). These are the hormonal modulators that work best with consistent daily dosing.

Hot flash reduction: most women notice improvement within 4-8 weeks on ERr 731 (based on the Heger et al. trial timeline).

What supplements help with perimenopause symptoms?

The most effective perimenopause protocols address multiple systems simultaneously. ERr 731 (Estro-Fem) is specifically studied for hot flashes and night sweats.

What is ERr 731 and does it work for hot flashes?

ERr 731 is a standardized extract of Siberian rhapontic rhubarb root that selectively binds estrogen receptor beta more than alpha. In the Heger et al.

Is pregnenolone safe during perimenopause?

Pregnenolone is a precursor to all steroid hormones - it sits at the top of the cascade and allows the body to allocate hormone raw material as needed during the transition. At supplemental doses it is generally well tolerated, but it should be used with practitioner guidance, hormone panel monitoring, and not alongside exogenous hormone therapy without supervision.

DIM and ERr 731 both modulate estrogen pathways. Consult your oncologist if you have a history of ER-positive cancer.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen.